The overarching goal of the Center for Cardiovascular Simulation (CCS) is to provide cardiovascular scientists and clinicians with advanced simulations for the rational development of treatments for cardiovascular disease. Such simulations can ultimately lead to reduction in development time, lowering of morbidity and mortality, reduced re-operative rates, and lessened post-operative recovery time. Our specific research focus is the simulation of the biomechanical function of the cardiovascular system at the continuum-cellular, micro-fibrous tissue, and whole organ levels. To achieve this, we utilize integrated computational/experimental approaches that incorporate the latest biomechanical/biomedical data and mechanobiological information to develop an improved understanding of pathophysiology. Fundamental to our approach will be the development and implementation of novel simulation technologies that exploit advances in computational methods to reduce the current trial-and-error approaches. Ultimately, we hope to develop simulation tools that will provide detailed dynamic information on disease progress and allow for “what-if” scenarios to physicians and biomedical engineers to devise new interventions. The development and use of these tools in the context of patient-specific models will ultimately also allow clinicians to craft cardiovascular therapies that are optimized for the cardiovascular system of individuals, with a resulting increase in success and decrease in risk of adverse side effects.

Michael Sacks, Director

Mitral Valve Modeling Bicuspid Heart Valve Fatigue Damage Models Ventricular Myocardium Model Multi-Scale Modeling of Active Contraction in Aortic Valve Tissues Growing pulmonary artery Heart Models for Ventricular Research and Development